This site contains an article that describes the use of surface plasmon resonance (SPR) spectroscopy to monitor real-time protein binding with fullerenes and carbon nanotubes. The introductory section provides a brief description of SPR and how it works. It next talks about the features of the Texas Instrument’s SPR, known as Speetra, which is a small self-contained apparatus for light measurements. It is followed by sections discussing the properties of fullerenes and carbon nanotubes, and the methods of surface binding with monoclonal antibodies. Experimental procedures are discussed followed by example results. An analysis and explanation of results in the concluding discussion section provides useful guidance to students and practitioners.