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Techniques

Primer for Liquid Chromatography – Agilent LC Handbook

A primer for liquid chromatography provided by Agilent Technologies. This publication reviews all aspects of fundamental liquid chromatography (LC).  The material covered is similar to might be found in an analytical chemistry textbook.  It is especially well-suited for first time users of liquid chromatography. Reviews of fundamental math, instrument design, and method development are included.  In…

Introduction to Mass Spectrometry Video

This video, part of the knowbeetutoring collection available from Wordpress.com offers a basic but effective introduction to ion production of organic molecules in an electron ionization spectrometer. The basis for fragmentation is explained for the propane molecule using very clear graphics. It is an excellent first exposure to the technique, and supplies a very solid…

ESTIMATION OF MEASUREMENT UNCERTAINTY IN CHEMICAL ANALYSIS

This site offers an introductory course (as a MOOC) on the estimation of measurement uncertainty specifically related to chemical analysis (analytical chemistry). The course gives the main concepts and mathematical apparatus of measurement uncertainty estimation and introduces two principal approaches to measurement uncertainty estimation – the ISO GUM modeling approach (aa “bottom-up”  approach) and the single-lab…

TOF Tutorial

A basic tutorial on the principles of Time-of-flight mass spectrometer design, presenting the concepts of ionization, acceleration from an ion source, energy dispersion of the ions due to space dispersion in the source, and the use of an ion mirror to focus this dispersion. The two-field source, the ion mirror, and the MCP ion detector is…

Analytical Chemistry 2.0: Chromatographic and Electrophoretic Methods

This chapter from David Harvey's complete e-text covers the general theory of column chromatography, GC, HPLC, and electrophoresis. Available as a downloadable pdf this 102 page chapter includes diagrams, examples and problems and provides an excellent introduction to separations. The website is available here .

Raman Spectroscopy Tutorial and FAQs

Horiba scientists wrote this tutorial to help people learn about Raman spectroscopy. The authors write clearly and provide great illustrations to accompany the text. The tutorial addresses the theory of Stokes & anti-Stokes Raman scattering, SERS and other techniques. In addition, the tutorial introduces the instruments needed for Raman experiments - like lasers, optics, and microscopes.…
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